Kisspeptin 10mg

Compound Overview

Kisspeptin 10mg is a lyophilized peptide preparation supplied by Amino Apex for qualified laboratory research. Kisspeptins are a family of biologically active peptides derived from the KISS1 precursor protein. Kisspeptin-10 (KP-10) is a ten-amino-acid peptide investigated for its interactions with the kisspeptin receptor (KISS1R), historically known as GPR54. The KISS1/KISS1R signaling system has been extensively investigated in relation to gonadotropin-releasing hormone (GnRH) regulation, hypothalamic signaling, reproductive neuroendocrinology, and G protein-coupled receptor activity. Experimental studies have examined how kisspeptin signaling participates in endocrine feedback mechanisms, reproductive maturation, and communication between hypothalamic neurons and downstream hormonal pathways. A 2022 peer-reviewed review published in Frontiers in Endocrinology examined kisspeptin receptor signaling and its relationship with GnRH regulation and the hypothalamic-pituitary-gonadal axis. The publication provides scientific context for understanding kisspeptin-associated neuroendocrine pathways. Foundational genetic research also established the importance of GPR54 signaling in reproductive development. A 2003 study published in The New England Journal of Medicine investigated the relationship between GPR54 function and pubertal development. These publications provide scientific background on kisspeptin-related pathways and do not establish therapeutic effectiveness or safety for the Amino Apex research material.

Molecular & Structural Research

Kisspeptin-10 consists of 10 amino-acid residues with the sequence:

YNWNSFGLRF-NH₂

Three-letter representation:

Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂

The C-terminal amide group is an important structural feature of Kisspeptin-10 and is part of the biologically active peptide structure.

Its molecular formula is:

C₆₃H₈₃N₁₇O₁₄

with an approximate molecular mass of:

1,302.4 g/mol

Kisspeptin-10 is associated with CAS Number 374675-21-5.

Kisspeptin peptides interact with KISS1R/GPR54, making KP-10 relevant to studies of GPCR activation, peptide-receptor interactions, intracellular signaling, and neuroendocrine pathway regulation.

Research Applications

Kisspeptin-10 may be studied in appropriately designed laboratory research involving:

• KISS1R / GPR54 receptor signaling
• GnRH-associated neuroendocrine pathways
• Hypothalamic signaling research
• Gonadotropin-associated signaling
• Hypothalamic-pituitary-gonadal axis research
• Reproductive neuroendocrinology
• Endocrine feedback mechanisms
• Puberty-associated signaling research
• Sex-steroid feedback pathways
• Metabolic regulation of reproductive signaling
• Peptide-receptor interaction studies
• GPCR signaling research
• Kisspeptin analogue characterization
• Comparative neuropeptide research
• Analytical peptide characterization

The KISS1/KISS1R system has been studied extensively in relation to GnRH secretion, gonadotropin regulation, puberty, reproductive endocrine signaling, and sex-steroid feedback mechanisms.

These categories describe areas of scientific investigation and do not constitute therapeutic or clinical-use recommendations.

Preclinical Research Context

Kisspeptin biology has been investigated in biochemical systems, cellular models, animal studies, and human physiological research.

Genetic and experimental research established KISS1R/GPR54 signaling as an important component of reproductive neuroendocrine regulation, particularly through its relationship with GnRH neurons and downstream gonadotropin signaling.

Research has also examined how Kiss1 neurons respond to sex-steroid feedback, metabolic signals, environmental factors, and neuroendocrine regulatory networks.

Although the KISS1/KISS1R system is well characterized as a research pathway, experimental findings should be interpreted within the conditions and limitations of each study rather than assumed to establish therapeutic effects.

Analytical Documentation

Amino Apex provides batch-specific analytical documentation for tested lots. Individual lot documentation may include chromatographic purity analysis and other analytical information associated with the tested sample.

Because analytical characteristics may differ by production lot, the Certificate of Analysis for the applicable batch should be used as the source of measured purity and quality-control results.

Refer to the COA panel on this page or the Amino Apex COA Library for available batch documentation.

Storage & Laboratory Handling

This material should be handled only by qualified personnel using procedures appropriate for laboratory peptide materials.

Storage and handling should follow the conditions specified in the applicable product and batch documentation.

Experimental preparation, concentration, assay conditions, and analytical methodology should be established by qualified researchers according to the requirements of their specific laboratory system.

Research Use Only

For laboratory research use only.

This material is not intended for human or animal use. It is not intended for diagnostic, therapeutic, food, cosmetic, or household applications and is not intended to diagnose, treat, cure, prevent, or mitigate any disease or medical condition.