Ipamorelin 10mg

Compound Overview

Ipamorelin 10mg is a lyophilized synthetic pentapeptide preparation supplied by Amino Apex for qualified laboratory research. Ipamorelin is classified as a growth hormone secretagogue and has been investigated for its activity at the growth hormone secretagogue receptor (GHS-R1a), a G protein-coupled receptor involved in endocrine signaling. Published preclinical research has examined ipamorelin's receptor pharmacology, growth hormone secretagogue activity, and selectivity relative to other compounds in its pharmacological class. These characteristics have made ipamorelin relevant to experimental investigations involving pituitary signaling, ghrelin-receptor biology, neuroendocrine regulation, and peptide–receptor interactions. A 1998 peer-reviewed study published in the European Journal of Endocrinology investigated ipamorelin's growth hormone secretagogue activity and pharmacological selectivity in experimental models, contributing to the scientific understanding of its endocrine signaling characteristics. Additional research has examined the compound's pharmacokinetic properties. A 1998 peer-reviewed study published in Xenobiotica compared ipamorelin with other peptide growth hormone secretagogues in experimental rat models. These publications provide scientific background and do not establish clinical safety or therapeutic effectiveness for the Amino Apex research material.

Molecular & Structural Research

Ipamorelin consists of five residues represented as:

Aib-His-D-2-Nal-D-Phe-Lys-NH₂

Expanded structural notation:

H-Aib-His-D-2Nal-D-Phe-Lys-NH₂

The sequence incorporates:

• Aib — aminoisobutyric acid
• Histidine
• D-2-Nal — D-2-naphthylalanine
• D-phenylalanine
• Lysine
• C-terminal amide

These noncanonical residues distinguish Ipamorelin from conventional peptides composed exclusively of naturally occurring L-amino acids and make it particularly relevant to peptidomimetic design and structure-activity relationship research.

Its molecular formula is:

C₃₈H₄₉N₉O₅

with an approximate molecular mass of:

711.9 g/mol

Ipamorelin is associated with CAS Number 170851-70-4 and research identifier NNC-26-0161.

Research Applications

Ipamorelin may be studied in appropriately designed laboratory research involving:

• GHSR / ghrelin-receptor signaling
• Growth hormone secretagogue pharmacology
• Pituitary somatotroph signaling
• Growth-hormone release pathways
• Neuroendocrine signaling
• Peptide-receptor interaction studies
• GPCR-associated signaling
• Growth hormone secretagogue selectivity
• Peptidomimetic structure-function research
• Noncanonical amino-acid peptide design
• Structure-activity relationship studies
• Comparative GHRP research
• Pituitary hormone signaling
• Analytical peptide characterization

The original pharmacological characterization of Ipamorelin reported growth-hormone-releasing activity with greater selectivity for GH release than earlier GHRP compounds, making receptor selectivity a central area of Ipamorelin research.

These categories describe areas of scientific investigation and do not constitute therapeutic or clinical-use recommendations.

Preclinical Research Context

Ipamorelin has been investigated in cellular assays, isolated pituitary systems, animal models, and clinical-development research.

Its early characterization included experiments using primary rat pituitary cells and in-vivo animal models to evaluate growth-hormone secretagogue activity and hormone-release selectivity.

Compared with several earlier growth hormone-releasing peptides, experimental studies reported that Ipamorelin did not produce comparable increases in ACTH or cortisol under the conditions tested, which contributed to its characterization as a comparatively selective growth hormone secretagogue.

The molecular and endocrine effects observed in experimental systems should be interpreted within the specific model, assay conditions, concentrations, and limitations of each study and should not be assumed to establish effects for an individual research-material lot.

Analytical Documentation

Amino Apex provides batch-specific analytical documentation for tested lots. Individual lot documentation may include chromatographic purity analysis and other analytical information associated with the tested sample.

Because analytical characteristics may differ by production lot, the Certificate of Analysis for the applicable batch should be used as the source of measured purity and quality-control results.

Refer to the COA panel on this page or the Amino Apex COA Library for available batch documentation.

Storage & Laboratory Handling

This material should be handled only by qualified personnel using procedures appropriate for laboratory peptide materials.

Storage and handling should follow the conditions specified in the applicable product and batch documentation.

Experimental preparation, concentration, assay conditions, and analytical methodology should be established by qualified researchers according to the requirements of their specific laboratory system.

Research Use Only

For laboratory research use only.

This material is not intended for human or animal use. It is not intended for diagnostic, therapeutic, food, cosmetic, or household applications and is not intended to diagnose, treat, cure, prevent, or mitigate any disease or medical condition.