Semax 10mg

Compound Overview

Semax 10mg is a lyophilized synthetic heptapeptide preparation supplied by Amino Apex for qualified laboratory research. Semax is derived from the adrenocorticotropic hormone (ACTH) sequence and consists of the ACTH(4–7) fragment extended with the C-terminal tripeptide Pro-Gly-Pro. Its seven-amino-acid sequence is Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP), also designated ACTH(4–7)-PGP. Experimental research has investigated Semax in relation to neurotrophin gene expression, brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neuronal signaling, and cellular responses to experimental ischemic conditions. Preclinical studies have examined its influence on neurotrophin-associated pathways and regulatory gene-expression mechanisms in nervous-system models. These findings remain dependent on experimental conditions, and Semax's complete molecular mechanisms are not fully characterized. A 2007 peer-reviewed study published in Neuroscience Letters investigated Semax-associated changes in brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) gene expression in experimental rat brain models. The publication provides scientific context for research involving neurotrophin regulation and neuronal signaling pathways. Additional research has examined Semax under experimental conditions involving cerebral ischemia. A 2009 peer-reviewed study published in Cellular and Molecular Neurobiology investigated the effects of Semax and Pro-Gly-Pro on neurotrophin and receptor gene transcription in rats subjected to experimental cerebral ischemia. These publications provide scientific background and do not establish therapeutic effectiveness or safety for the Amino Apex research material.

Molecular & Structural Research

Semax consists of 7 amino-acid residues with the sequence:

MEHFPGP

Three-letter representation:

Met-Glu-His-Phe-Pro-Gly-Pro

Full structural notation:

H-Met-Glu-His-Phe-Pro-Gly-Pro-OH

Its molecular formula is:

C₃₇H₅₁N₉O₁₀S

with an approximate molecular mass of:

813.9 g/mol

Semax is associated with CAS Number 80714-61-0.

The peptide contains the ACTH(4–7) tetrapeptide region joined to a Pro-Gly-Pro C-terminal sequence. This structural arrangement has made Semax relevant to experimental studies of regulatory peptide signaling, peptide stability, structure-function relationships, and neurotrophic pathways.

Semax has also been investigated for its ability to interact with copper(II) ions, providing an additional area of research involving peptide-metal coordination and molecular interactions.

Research Applications

Semax may be studied in appropriately designed laboratory research involving:

• Neurotrophic-factor signaling
• BDNF-associated pathways
• NGF-associated pathways
• BDNF/TrkB signaling research
• Neuropeptide regulation
• Neuronal gene-expression studies
• Glial-cell signaling research
• Cellular stress-response pathways
• Peptide structure-function studies
• ACTH-fragment research
• Regulatory peptide signaling
• Peptide-metal interaction studies
• Comparative neuropeptide research
• Analytical peptide characterization

Research in rat brain and cultured glial-cell systems has reported Semax-associated changes in BDNF and NGF expression, while other work has examined changes in BDNF protein and TrkB signaling.

These categories describe areas investigated in scientific literature and do not constitute therapeutic or clinical-use recommendations.

Preclinical Research Context

Semax has been investigated primarily through biochemical studies, cultured-cell systems, and animal models, with additional historical human research appearing in the literature.

Experimental studies have examined Semax-associated changes in BDNF, NGF, TrkB, neuronal gene expression, and nervous-system signaling pathways. The direction and magnitude of these responses can vary according to the tissue, experimental model, exposure conditions, and observation period.

Research has also identified specific and reversible Semax-binding activity in rat basal-forebrain membrane preparations, although the complete molecular mechanism of Semax remains incompletely characterized.

Findings from experimental systems should not be assumed to establish clinical safety, efficacy, or therapeutic effects in humans.

Analytical Documentation

Amino Apex provides batch-specific analytical documentation for tested lots. Individual lot documentation may include chromatographic purity analysis and other analytical information associated with the tested sample.

Because analytical characteristics may differ by production lot, the Certificate of Analysis for the applicable batch should be used as the source of measured purity and quality-control results.

Refer to the COA panel on this page or the Amino Apex COA Library for available batch documentation.

Storage & Laboratory Handling

This material should be handled only by qualified personnel using procedures appropriate for laboratory peptide materials.

Storage and handling should follow the conditions specified in the applicable product and batch documentation.

Experimental preparation, concentration, assay conditions, and analytical methodology should be established by qualified researchers according to the requirements of their specific laboratory system.

Research Use Only

For laboratory research use only.

This material is not intended for human or animal use. It is not intended for diagnostic, therapeutic, food, cosmetic, or household applications and is not intended to diagnose, treat, cure, prevent, or mitigate any disease or medical condition.