Selank 10mg

Compound Overview

Selank 10mg is a lyophilized synthetic heptapeptide preparation supplied by Amino Apex for qualified laboratory research. Selank is a seven-amino-acid peptide derived from the naturally occurring immunomodulatory peptide tuftsin, with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). It has been investigated in experimental studies involving GABAergic neurotransmission, neurochemical signaling, gene-expression regulation, and peptide–receptor interactions. Preclinical research has examined Selank's relationship with GABA receptor-associated pathways, neurotransmitter regulation, and cellular signaling mechanisms. Experimental investigations have reported changes in genes associated with neurotransmitter receptors, transporters, and ion channels. Although these findings suggest possible interactions with GABAergic systems, Selank's complete molecular mechanisms remain incompletely characterized. A 2016 peer-reviewed study published in Frontiers in Pharmacology investigated Selank-associated changes in neurotransmission-related gene expression in rat frontal cortex tissue. Researchers examined genes associated with GABA receptors, neurotransmitter transporters, ion channels, and other signaling systems, providing experimental evidence of Selank-associated changes in neurochemical gene expression. Additional molecular research has examined Selank's interactions with GABA-related receptor systems. A 2018 peer-reviewed study published in Protein & Peptide Letters investigated Selank's effects on GABA binding using experimental receptor-binding assays, reporting findings consistent with allosteric modulation. These publications provide scientific background and do not establish therapeutic effectiveness or safety for the Amino Apex research material.

Molecular & Structural Research

Selank consists of 7 amino-acid residues with the sequence:

TKPRPGP

Three-letter representation:

Thr-Lys-Pro-Arg-Pro-Gly-Pro

Its molecular formula is:

C₃₃H₅₇N₁₁O₉

with an approximate molecular mass of:

751.9 g/mol

Selank is associated with CAS Number 129954-34-3. PubChem identifies the peptide as H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH.

The peptide's structure includes the tuftsin-derived TKPR region and a C-terminal Pro-Gly-Pro sequence. This composition has made Selank relevant to peptide structure-function studies, neuropeptide research, enzymatic degradation studies, and regulatory-peptide signaling investigations.

Research Applications

Selank may be studied in appropriately designed laboratory research involving:

• GABAergic neurotransmission
• GABA receptor-associated signaling
• Neurotransmitter gene-expression research
• Dopaminergic signaling pathways
• Serotonergic signaling pathways
• Neuropeptide regulation
• BDNF-associated research
• Neurotrophic-factor signaling
• Peptide metabolism and degradation
• Enkephalin-associated biochemical research
• Regulatory peptide structure-function studies
• Monoaminergic signaling
• Comparative neuropeptide research
• Analytical peptide characterization

Rat and cellular studies have reported Selank-associated changes in genes involved in GABAergic and broader neurotransmission pathways, while separate studies have examined BDNF expression and monoaminergic systems.

These categories describe areas of scientific investigation and do not constitute therapeutic or clinical-use recommendations.

Preclinical Research Context

Selank has been investigated primarily through biochemical experiments, cultured-cell systems, and animal models, with additional historical clinical research reported in the scientific literature.

Experimental work in rat frontal cortex found changes in expression of numerous genes associated with GABA receptors, neurotransmitter transport, ion channels, and other neurotransmission systems following Selank exposure. Researchers have proposed GABAergic modulation as one possible component of its molecular activity.

Additional preclinical studies have examined Selank in relation to serotonin and noradrenaline systems, BDNF expression, and enzymatic degradation of enkephalins.

The molecular mechanisms associated with Selank remain incompletely characterized, and findings from experimental models should not be assumed to establish clinical safety, efficacy, or therapeutic effects.

Analytical Documentation

Amino Apex provides batch-specific analytical documentation for tested lots. Individual lot documentation may include chromatographic purity analysis and other analytical information associated with the tested sample.

Because analytical characteristics may differ by production lot, the Certificate of Analysis for the applicable batch should be used as the source of measured purity and quality-control results.

Refer to the COA panel on this page or the Amino Apex COA Library for available batch documentation.

Storage & Laboratory Handling

This material should be handled only by qualified personnel using procedures appropriate for laboratory peptide materials.

Storage and handling should follow the conditions specified in the applicable product and batch documentation.

Experimental preparation, concentration, assay conditions, and analytical methodology should be established by qualified researchers according to the requirements of their specific laboratory system.

Research Use Only

For laboratory research use only.

This material is not intended for human or animal use. It is not intended for diagnostic, therapeutic, food, cosmetic, or household applications and is not intended to diagnose, treat, cure, prevent, or mitigate any disease or medical condition.