KPV 10mg

Compound Overview

KPV 10mg is a lyophilized tripeptide preparation supplied by Amino Apex for qualified laboratory research. KPV, also known as Lys-Pro-Val, is a three-amino-acid peptide corresponding to the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH). Its simplified molecular structure has made it relevant to experimental investigations involving peptide signaling, inflammatory-response pathways, epithelial-cell biology, and melanocortin-associated mechanisms. Preclinical research has examined KPV in relation to NF-κB-associated signaling, cytokine regulation, peptide transport, and cellular responses to inflammatory or oxidative stress. Experimental studies involving intestinal epithelial cells, keratinocytes, macrophage-related systems, and animal models have investigated its biological activity. Although KPV originates from the α-MSH sequence, its molecular interactions may involve mechanisms that differ from those of the parent peptide. A 2008 peer-reviewed study published in Gastroenterology investigated KPV transport through the peptide transporter PepT1 and examined associated inflammatory signaling pathways in experimental cellular and mouse models. The research included investigations of NF-κB and MAPK-associated responses, providing scientific context for intestinal epithelial signaling studies. Additional research has examined KPV in experimental models involving keratinocyte responses to environmental stress. A 2025 peer-reviewed study investigating KPV and keratinocyte responses examined reactive oxygen species, inflammatory signaling, and cellular responses to particulate matter exposure. These publications provide scientific background and do not establish therapeutic effectiveness or safety for the Amino Apex research material.

Molecular & Structural Research

KPV consists of 3 amino-acid residues with the sequence:

KPV

Three-letter representation:

Lys-Pro-Val

Structural notation:

H-Lys-Pro-Val-OH

Its molecular formula is:

C₁₆H₃₀N₄O₄

with an approximate molecular mass of:

342.43 g/mol

KPV is associated with CAS Number 67727-97-3.

KPV represents the C-terminal 11–13 region of α-MSH. Experimental work has examined whether this minimal sequence preserves signaling characteristics associated with the parent melanocortin peptide, including effects involving intracellular calcium, NF-κB-associated signaling, and other cellular-response pathways.

Research Applications

KPV may be studied in appropriately designed laboratory research involving:

• α-MSH fragment research
• Melanocortin-associated signaling
• NF-κB-associated pathways
• Cytokine-signaling research
• Keratinocyte-response studies
• Epithelial-cell signaling
• Innate immune signaling
• Cell-migration research
• Gastrointestinal cellular models
• Macrophage-response studies
• Peptide structure-function relationships
• Short-peptide signaling
• Comparative melanocortin research
• Analytical peptide characterization

Published research has examined KPV in human keratinocytes, macrophage-related systems, and animal models of gastrointestinal and inflammatory signaling.

These categories describe areas of scientific investigation and do not constitute therapeutic or clinical-use recommendations.

Preclinical Research Context

KPV has been investigated primarily through cellular, biochemical, and animal-model research.

Studies have examined its effects on NF-κB activation, nitric-oxide-associated signaling, inflammatory-cell migration, epithelial responses, and melanocortin-related cellular pathways. Importantly, some experiments suggest that KPV's signaling does not always mirror the receptor-dependent mechanisms of full-length α-MSH, indicating that its molecular activity may involve multiple or context-dependent pathways.

Research has also investigated KPV in intestinal inflammation models and demonstrated biological activity even in models involving altered MC1R function, further supporting continued investigation of mechanisms beyond a simple single-receptor model.

Findings from experimental systems should not be assumed to establish clinical safety, efficacy, or therapeutic effects in humans.

Analytical Documentation

Amino Apex provides batch-specific analytical documentation for tested lots. Individual lot documentation may include chromatographic purity analysis and other analytical information associated with the tested sample.

Because analytical characteristics may differ by production lot, the Certificate of Analysis for the applicable batch should be used as the source of measured purity and quality-control results.

Refer to the COA panel on this page or the Amino Apex COA Library for available batch documentation.

Storage & Laboratory Handling

This material should be handled only by qualified personnel using procedures appropriate for laboratory peptide materials.

Storage and handling should follow the conditions specified in the applicable product and batch documentation.

Experimental preparation, concentration, assay conditions, and analytical methodology should be established by qualified researchers according to the requirements of their specific laboratory system.

Research Use Only

For laboratory research use only.

This material is not intended for human or animal use. It is not intended for diagnostic, therapeutic, food, cosmetic, or household applications and is not intended to diagnose, treat, cure, prevent, or mitigate any disease or medical condition.