Oxytocin 5mg

Compound Overview

Oxytocin 5mg is a lyophilized synthetic nonapeptide preparation supplied by Amino Apex for qualified laboratory research. Oxytocin is a naturally occurring cyclic peptide hormone composed of nine amino-acid residues. It functions as both a neurohypophyseal hormone and a signaling neuropeptide, making it relevant to investigations involving neuroendocrine regulation, peptide-receptor interactions, and cellular signaling mechanisms. Experimental research has extensively characterized oxytocin's interactions with the oxytocin receptor (OXTR), a G protein-coupled receptor involved in multiple intracellular signaling pathways. Classical OXTR activation involves Gαq/11-mediated phospholipase C (PLC) signaling, generating inositol trisphosphate (IP3) and diacylglycerol (DAG). These pathways contribute to intracellular calcium mobilization, protein kinase C activation, and downstream cellular responses. A 2018 peer-reviewed review published in Physiological Reviews examined oxytocin receptor biology, intracellular signaling mechanisms, and receptor-associated responses in central and peripheral physiological systems. The publication discusses OXTR signaling through G proteins and downstream pathways involving PLC, PKC, MAPK, and other regulatory mechanisms. Additional structural research has investigated the molecular interactions between oxytocin and its receptor. A 2022 peer-reviewed study published in Nature Communications used cryo-electron microscopy to characterize the active human oxytocin receptor bound to oxytocin, providing structural insights into ligand recognition, receptor activation, and receptor selectivity. These publications provide scientific background and do not establish the safety, efficacy, or suitability of the Amino Apex research material for clinical use.

Molecular & Structural Research

Oxytocin consists of 9 amino-acid residues with the sequence:

CYIQNCPLG-NH₂

Three-letter representation:

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH₂

A disulfide bond between Cys1 and Cys6 forms a six-residue cyclic region, while the remaining residues form a short C-terminal tail. This cyclic architecture is a defining structural feature of oxytocin.

Its molecular formula is:

C₄₃H₆₆N₁₂O₁₂S₂

with an approximate molecular mass of:

1,007.2 g/mol

Oxytocin is associated with CAS Number 50-56-6.

Oxytocin shares structural characteristics with vasopressin, another cyclic neurohypophyseal nonapeptide, making the two peptide systems relevant to comparative studies of sequence variation, receptor selectivity, peptide conformation, and GPCR signaling.

Research Applications

Oxytocin 5mg may be studied in appropriately designed laboratory research involving the following molecular and cellular pathways:

• Oxytocin receptor (OXTR) signaling
• G-protein-coupled receptor pharmacology
• Gαq/11-associated signaling
• Phospholipase C signaling
• IP₃ and DAG-associated pathways
• Intracellular calcium mobilization
• Protein kinase C signaling
• MAPK-associated pathways
• Neuroendocrine signaling
• Neuronal and synaptic signaling
• Smooth-muscle cellular signaling
• Receptor regulation and desensitization
• Peptide-receptor interaction studies
• Comparative oxytocin/vasopressin research
• Cyclic peptide structure-function studies
• Analytical peptide characterization

OXTR activation is particularly well characterized through the Gq/PLC/IP₃ pathway, which produces changes in intracellular calcium and downstream cellular signaling.

These categories describe areas of scientific investigation and do not constitute therapeutic or clinical-use recommendations.

Preclinical Research Context

Oxytocin biology has been investigated extensively across biochemical systems, receptor-expression models, cultured cells, animal studies, and human physiology research.

Research has examined OXTR signaling in reproductive, neuronal, cardiovascular, and other cellular systems, with receptor responses varying according to tissue type, receptor expression, intracellular signaling machinery, and experimental conditions.

At the molecular level, research has characterized Gq/11-mediated PLC activation, calcium mobilization, PKC signaling, receptor phosphorylation, β-arrestin recruitment, and receptor internalization/desensitization.

Although oxytocin itself has an established clinical pharmacology, findings from published studies should not be assumed to establish the characteristics, safety, efficacy, or intended use of an individual Amino Apex research-material lot.

Analytical Documentation

Amino Apex provides batch-specific analytical documentation for tested lots. Individual lot documentation may include chromatographic purity analysis and other analytical information associated with the tested sample.

Because analytical characteristics may differ by production lot, the Certificate of Analysis for the applicable batch should be used as the source of measured purity and quality-control results.

Refer to the COA panel on this page or the Amino Apex COA Library for available batch documentation.

Storage & Laboratory Handling

This material should be handled only by qualified personnel using procedures appropriate for laboratory peptide materials.

Storage and handling should follow the conditions specified in the applicable product and batch documentation.

Experimental preparation, concentration, assay conditions, and analytical methodology should be established by qualified researchers according to the requirements of their specific laboratory system.

Research Use Only

For laboratory research use only.

This material is not intended for human or animal use. It is not intended for diagnostic, therapeutic, food, cosmetic, or household applications and is not intended to diagnose, treat, cure, prevent, or mitigate any disease or medical condition.